150 Muscle Quantity at C3 And/or L3 on Routine Trauma Series Computed Tomography Correlate with Brain Frailty and Clinical Frailty Scale: A Cross-Sectional Study

Abstract Background Sarcopenia is increasingly recognised to impact the quality of life and patient outcomes. The relationship with brain frailty unknown. Objectives Assess if muscle mass at C3 correlates L3 on routine trauma imaging. for associations between muscle-mass, brain-frailty, Clinical Frailty Scale (CFS) Method Routine trauma-series CT scans were retrospectively analysed patients aged ≥16-years-old admitted Queen-Elizabeth-Hospital in January2020. Paravertebral, sternocleidomastoid, total cross-sectional-area (CSA) (C3-SMM), psoas CSA (TPA), (L3-SMM), adipose calculated. Brain-frailty scores calculated assessing leukoaraiosis, cerebral atrophy, old vascular lesions/infarcts. CFS was from clinical notes. We assessed correlation against age, CFS, brain-frailty using Pearson’s correlations. Results included 111 this study (mean age 49, SD 25.6; 65.8% female). C3-SMM strongly correlated L3-SMM (r=0.746, p<0.001). Paravertebral sternocleidomastoid (paravertebral: r=0.814, p<0.001; sternocleidomastoid: TPA L3- SMM (r=0.800, Sternocleidomastoid both negatively moderately (sternocleidomastoid: r=−0.460, TPA: r=−0.468, p<0.001), r=−0.414, r=−0.431, r=−0.395, r=−0.436, Adipose did not correlate or muscle-mass. Conclusions Muscle-mass relates muscle-mass L3. trauma-imaging associated brain-frailty.